SecurRIN™ Advanced RNase Inhibitor: Robust RNA protection during sample preparation.

SecurRIN™ Advanced RNase Inhibitor: Robust RNA protection during sample preparation.


  • SARS-CoV-2 RNA extraction, COVID-19 assays.
  • Prevention of RNA degradation during cDNA synthesis, RNA extraction and storage, during in vitro transcription and translation.
  • Monoclonal antibody preparation procedures.


  • Efficient RNAse inhibition even at higher temperatures up to 60°C.
  • RNA protection from hydrolysis by RNases A, B and C.
  • Economical & stable for weeks at ambient temperature.
  • Robust, works well at 5.5 to 9.0 pH, with 0.5 - 1 mM DTT.


Product sizes
2500 units
12500 units

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Selected Catalog #: RNI0301
Product information "SecurRIN™ Advanced RNase Inhibitor"

SecurRIN™ Advanced RNase Inhibitor is a premium tool for RNA protection from degradation during enzymatic reactions, storage or extraction. It is an extraordinary stable and robust enzyme: it works at up to 60°C temperature, remains active after weeks of room temperature exposure and multiple freezing thawing cycles. It is active in different buffer conditions within a broad pH range of 5.5 to 9.0, and within 0.5 - 1 mM concentration of DTT.

SecurRIN™ Advanced RNase Inhibitor is a 50 kDa non-covalent inhibitor of RNase A, RNase B, and RNase C binding them in a 1 to 1 ratio. It is a recombinant protein derived from E. coli strain carrying human placenta RNase Inhibitor gene.
SecurRIN™ Advanced RNase Inhibitor does not inhibit RNAses H, 1, T1, T2 and S1 Nuclease. It influences neither the activity nor the performance of DNA polymerases and of Reverse Transcriptases. The enzyme is free from DNAses and RNAses.

Ribonuclease Inhibitor is a protein that protects RNA samples from degradation by ribonucleases. Ribonucleases are present everywhere in laboratory environment, they are very robust and ubiquitous enzymes that rapidly degrade RNA by destroying valuable RNA samples during molecular biology or diagnostics workflows.

RNase inhibitor binds to RNases and inactivates these enzymes, ensuring the integrity and stability of RNA samples during such processes as RNA isolation, clean-up, cDNA synthesis, RT-qPCR and other applications.

A good RNase inhibitor should have high affinity for RNases and strong inhibitory activity under a wide variety of buffer conditions. It shall tolerate different pH values, salt concentrations and shall have high affinity to different types of RNases. It should also be stable under higher temperatures and easy to use in all common RNA-related buffers with minimal interference with downstream applications. Furthermore, it is especially important, that the Inhibitor itself is pure and free from contaminating RNases.

highQu offers SecurRIN™ Advanced RNase Inhibitor for RNA protection from degradation during enzymatic reactions, storage or extraction. Is is a 50 kDa non-covalent inhibitor of RNase A, RNase B, and RNase C.

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